• Register
  • Login
  • Bookmark this page!
Skip Navigation LinksHome Page    >    Multiple sclerosis
Pregnancy links...
Health links...
Genetics links...
Medical links...
Autism links...
Other links...

Multiple sclerosis

Types and clinical signs ( Multiple sclerosis symptoms )

In this disease there is localized damage in the white matter of the brain that manifests in neurological deficits corresponding to the region of the brain where the damage has occurred. The disease occurs paroxysmally (in attacks) and two episodes each lasting more than 24 hours with an interval of more than a month between them are needed to establish the diagnosis.

The neurological deficits are diverse.

Inheritance pattern

Multifactorial - there is a genetic basis, and an environmental trigger, such as a particular virus, may lead to the onset of the disease in genetically predisposed individuals.


Not known. Women are affected twice as often as men. The age of onset in most affected individuals is between the ages of 20 and 40 years.

Associated features that can be demonstrated in tests performed during pregnancy


What is the risk of recurrence in a subsequent pregnancy?

The brother of a female with multiple sclerosis has a 2.5% chance of having the same condition. Conversely the sister of an affected male has a 5% risk.

The brother of a male with multiple sclerosis has a 4% chance of having the same condition. Conversely the sister of an affected male has a 3% risk.

The identical twin of an affected individual has a 25% chance of also being affected. Conversely, a non-identical twin has the same risk as any other sibling - 2%.

The risk for children of a patient suffering from the disease is 2.5% irrespective of sex.

The risk for more distant relatives depends on the number of affected individuals in the family, the degree of relationship between the relatives and the affected individuals, etc., and is established within genetic counseling.

Molecular genetic information

Multiple Sclerosis

The gene for the disease and its location

One of the genes is situated, as in type 1 diabetes, in the region of the tissue matching (HLA) gene complex on chromosome 6.

Research is continuing in an attempt to find additional genes - mainly genes in the immune system - one of which is the gene PTPPRC on chromosome 1q31, in which mutations have been found in families of patients. These findings have not yet been proved and are not part of the standard clinical investigation, but serve as a marker.

Genetic testing

Diagnostic testing

In multiple sclerosis there are currently no reliable molecular tests. In specific families with many patients, it is possible to consider linkage analysis (see: Indirect testing for genetic markers in a family that has one or several patients - when there are a number of different genes that can each cause the disease - the gene, or most of the genes not having been located / identified / mapped - multifactorial diseases.

Carrier testing

There is no reliable carrier test for multiple sclerosis.

Fetal testing

There are no diagnostic molecular tests that can be performed in the fetus or newborn.

What is Multiple Sclerosis

Haven't found what you're looking for? Search for it here:   
Comments (19)

Friday, July 15, 2011 11:38 AM
(1) janicecolline56r  says:

Multiple Sclerosis

Interesting to read all the new responses, thanks for all the current news and updates. Hope to read more very soon.

Tuesday, January 17, 2012 12:29 PM
(2) veronika  says:

thanks for the medical information

Thanks for the medical information it will come in very handy for my school project!

Sunday, February 15, 2015 1:00 PM
(3) michealjohn  says:

get more information

Should there be an alternate enticing post you can impart next time, I'll be without a doubt sitting tight for it.

Saturday, February 21, 2015 11:36 PM
(4) michealjohn  says:

Online Business

As a Newbie, I am permanently exploring online for articles that can be of assistance to me. Thank you

Sunday, February 22, 2015 12:27 AM
(5) helen  says:

mobil casino

Effortlessly, the article is really the best point on this registry related issue. I fit in with your decisions and will energetically anticipate your next overhauls.

Sunday, February 22, 2015 9:18 PM
(6) zeeshan  says:

Verified Trader

Hmm… I read blogs on a similar topic, but i never visited your blog. I added it to favorites and i’ll be your constant reader.

Monday, February 23, 2015 6:31 AM
(7) dolly  says:

One Stop Place African Blog Website

Exclusive and Original content for the most and latest relevant entertainment news, beauty topics, fashion, news and celebrity gossip of African, African American and the African diaspora.

Tuesday, February 24, 2015 11:26 PM
(8) ren  says:

My Lead System Pro Review

Great post full of useful tips! My site is fairly new and I am also having a hard time getting my readers to leave comments. Analytics shows they are coming to the site but I have a feeling “nobody wants to be first”.

Wednesday, February 25, 2015 2:00 AM
(9) jenefer  says:


it's really nice and meanful. it's really cool blog. Linking is very useful thing.you have really helped lots of people who visit blog and provide them usefull information.

Friday, February 27, 2015 1:54 PM
(10) valcano  says:

Cab Service Crowley TX

Incredible post! I am really getting prepared to over this data, is extremely useful my companion. Likewise extraordinary blog here with the greater part of the important data you have. Keep doing awesome doing here.

Tuesday, March 31, 2015 3:51 AM
(11) asa  says:

Calculatoare Second Hand

Every thing the following article possesses has a really fashionable look as well as these kinds of content have become nearly impossible to find although thank The Almighty I found this informative article.

Tuesday, March 31, 2015 4:59 AM
(12) asda  says:

predicciones deportivas

Great info! I recently came across your blog and have been reading along. I thought I would leave my first comment. I don’t know what to say except that I have.

Wednesday, April 01, 2015 2:13 AM
(13) asd  says:

Apartamente berceni

Gain from that first special useful providing an abundance of assurance Effective throughout health supplement to help considerable. Considering if you ever implement satisfying together with looking for quite a few assurance however you can observe seriously confirmed possibilities.

Wednesday, April 01, 2015 4:50 AM
(14) sad  says:

homes in bucharest

I am in the middle of working on a school report on this topic and your post has helped me with the information I needed to complete it. Thanks.

Tuesday, April 28, 2015 11:38 PM
(15) Online HighSchoo  says:

Online Diploma

I enjoyed so much to read your blog. Generally writing skills is attained via practice but you are awesome writer. I am going to share it with my other friends on social networking sites. Keep continue your outstanding job.

Tuesday, May 05, 2015 2:16 AM
(16) 75 dofollow back  says:


This is also a very good post which I really enjoyed reading. It is not every day that I have the possibility to see something like this..

Friday, June 12, 2015 1:00 PM
(17) asasd  says:


I recently came across your blog and have been reading along. I thought I would leave my first comment. I don't know what to say except that I have enjoyed reading. Nice blog. I will keep visiting this blog very often.

Monday, September 07, 2015 1:54 AM
(18) joseph  says:


Sclerosis is very hard to overcome. The only way is to follow every suggestion of the practitioner without missing anything. This will definitely help and one can get relieved from the ailment without it effecting the daily chores.

Monday, September 07, 2015 1:59 AM
(19) brad  says:

I hope that

I hope that you have achieved great results and wish to continue my visit here. Keep up the good work.

Leave a Comment
Email (will not be published)
Website (optional)
Your Comment

Line and paragraph breaks are automatic.

Please type the characters you see in the picture:

All content Copyright © 2009-2011, Genetics of Pregnancy Encyclopedia Corporation. All rights reserved.